Coronavirus

In 2002, not all hotel guests became aware that they had all become hosts of an unknown virus. The virus killed 84 people in six months. The economy was in turmoil. The loss to the Asian Development Bank is 59 billion. The virus was named "Severe Acute Respiratory Syndrome Coronavirus" (SARS-COV) because the disease was known as "Severe Acute Respiratory Syndrome". That is not the end. A few years later, the "Middle East Respiratory Syndrome Coronavirus" (Mars-Cav) outbreak broke out in Saudi Arabia. It is known that the Mars-Kav virus is related to the Sars-Kav and as a result panic spread in an instant because the world had already seen the horrors of the Sars-Kav. Although later the "epidemiological report" or "epidemic." According to the "Statistical Report", the spread of infectious respiratory infections caused by Mars-Cove is lower than that of SARS-Cove. But even then, like Sars-Kav, Mars-Kav had a bad effect on the whole world. Many restrictions were imposed on the movement of the rest of the world with the infected regions of the world.

Towards the end of December 2019, Wuhan City, China:

People began to shake the hospital's claws on the sick body; Symptoms - fever, cough, shortness of breath, and muscle aches. Doctors said - "viral bilateral pneumonia" (ie, both lungs are infected with viral pneumonia). But within a short time, pneumonia swept the doctors' foreheads as the number of sick people skyrocketed. After delving deeper into the underlying causes of the disease, doctors realized that a new disease, disguised as pneumonia, was creeping into the patient's lungs and into the gastrointestinal tract. Nearly seventeen years after the catastrophic attack of the "Sars-Kav" virus on mankind in 2002, a harmful virus has reappeared in the human respiratory system with which humans have never been acquainted before.

It is understood that the virus belongs to the "iridoviruses" order according to taxonomy. The genetic material of the virus is "RNA". Or "ribonucleic acid" but many of our well-known RNA Like viruses (such as HIV or human immunodeficiency virus), it has its own "RNA." "DNA" Or "deoxyribonucleic acid" does not mix with the "DNA" of human cells.
Rather, after the virus enters the human cell, it deactivates the human cell's own "messenger RNA" (messenger RNA) to make its own "RNA." Who puts the human cell in the role of "messenger RNA". And two types of polyproteins follow the nucleotide sequence of that "messenger RNA" of the virus without the "ribosome" organ of the human cell being detected(Polyprotein molecules are many relatively small protein molecules that form a long chain-like molecule that is joined together by covalent bonds). Some of the sixteen types of "nonstructural proteins" (proteins that help cell function, not cell structure) that break down a type of polyprotein are some of the proteins that mimic the "RNA" of the virus. What exactly are the nucleotides in the "RNA" of the virus?

The process of copying what is there is called transcription) and "replication" (the process of creating new "RNA" according to the copied nucleotide sequence is called replication). ” Exactly - that is, the virus inevitably paves the way for its reproduction in human cells. The new infectious disease caused by this virus has been named "Corona Virus Disease-2019" or "Covid-19" which is causing death threats all over the world and the world's economy has come to a standstill. Of the four types of proteins that make up the virus particle, the most important is the "spike protein". The reason for calling it a "spike protein" is that this protein virus produces a myriad of "spike" or "thorn" -like components all over the particle that look like a "bright sun" or "solar corona" under a microscope. 

This scenario confirmed to scientists that the virus belonged to the "Coronaviridae" family. The virus was named "Novel Corona Virus" or "New Corona Virus" for the first time in human civilization. However, since the nucleotide sequence of the "RNA" of the SARS COV virus is seventy percent identical to that of the virus, and the same hosts or carriers that the SARS COV virus infects, the same hosts or carriers. The virus is later named "SARS-CV-2" or "Severe Acute Respiratory Syndrome Coronavirus-2" after comparing the way it is transmitted. According to the classification of viruses, the family to which this virus belongs, i.e. the "Coronaviridae" family, consists of four genera - "Alpha Coronavirus", "Beta Coronavirus", "Gamma Coronavirus" and "Delta Coronavirus". The "identity card" of the virus identifies the "beta coronavirus" as a genus. Also, its subgenus is "Cervicovirus" and the species is "Severe Acute Respiratory Syndrome Related Coronavirus".

SARS-COV-2 virion-particle formation and its entry into human cells:

A SARS-COV-2 virion-particle (if any virus carrier is outside the body or located between two cells in the carrier body is called "virion". Once it enters the carrier cell it is called "virus") is 50 to 200 nanometers in diameter. Like other beta coronaviruses, SARS-CV-2 particles are made up of four structural proteins - "spike protein", "envelope protein", "membrane protein" and "nucleocapsid protein". The "nucleocapsid protein" contains the "RNA" of the virus. The other three types of proteins together form the outer envelope of these virion-particles.

SARS-CV-2 has a special tendency to bind to human angiotensin-converting enzyme-2 (ACE-2 enzyme). There is an abundance of this enzyme in type 2 alveolar cells of the human lung. The abundance of this enzyme is also found in the glandular cells of the gastric epithelium, duodenal epithelium, and rectal epithelium, and in the endothelial cells and enterocytes of the small intestine. The SARS-COV-2 virion is used in the human cell with the help of its envelope's "Spike Protein". C. E. - 2 is attached to the enzyme and then the virion can enter the human cell in two main ways -

A) The virion can enter the "endosome" (the endosome is a membrane-encased chamber in any eukaryotic cell) by "fusion" or "attachment" of the wall of the "endosome" between its envelope and the human cell.
Or
B) The virion can enter the human cell directly by "fusion" of its envelope and the cell membrane of the human cell.

The virus “kills RNA. Virus ”but many of our known RNA. Like viruses (such as HIV), it has its own "RNA." Who converts it to "DNA" and does not mix it with the "DNA" of human cells. Rather, after the virus enters the human cell, it inactivates the human cell's own "messenger RNA" to make its own "RNA." Who puts the human cell in the role of "messenger RNA". And the "ribosome" organelle of the human cell, without realizing it, makes two types of polyproteins by following the nucleotide sequence of that "messenger RNA" of the virus. Some of the sixteen types of "nonstructural proteins" that are formed by breaking down a type of polyprotein are some of the proteins that mimic the "RNA" of the virus and are needed to produce many more viruses in the process of "transcription" and "replication". "RNA." Let us create exactly.

Symptoms of COVID-19 disease:

Among the many cases of COVID-19 infection that have been reported so far, ranging from minor symptoms and severe illness to death, these are just a few examples. We know that symptoms begin to appear in humans just after exposure to any harmful germs, chemicals, or radiation; This is called the "incubation period".

In the case of the SARS-CV-2 virus, the "incubation period" is roughly the same as that of the Mars-CV virus, i.e. two to 14 days. Notable among the symptoms are –

a. Fever b. Cough c. Shortness of breath d. Muscle pain

The occurrence of COVID-19 disease:

There may be some occasions before the "incubation period" begins after the SARS-CV-2 virus infection, such as –

Constant chest pain

The bluish expression on the face or lip

People with Covid-19 disease are more likely to get sick:

COVID - 19 is a new disease. In addition to the possible symptoms and occasions, we do not have complete information about the risk of this disease. People with this disease are more prone to get sick –

a. Those 65 years of age or older.
b. Those who have lung disease or problems or asthma. c. All those people who suffer from heart disease.
d. Those who have had cancer treatment or bone marrow transplantation or have uncontrolled AIDS, or have long-term use of corticosteroids have lost their immunity.
e. Although it is not yet clear what side effects Covid-19 may have on pregnant women, they need to be monitored as they are more prone to getting sick from any harmful virus infection.

How is Covid-19 disease spread?

The SARS-COV-2 virus is a natural mutation in the nucleotide sequence of the RNA of a predecessor virus (Which we know as natural mutations) Did the virus come or was the virus artificial, meaning "gene editing" by humans?
The process by which the virus is born by changing the nucleotide sequence of the RNA of a virus (what we call a "genetically engineered" virus) is controversial.

If the organisms of a particular species or subspecies carry a large number of certain pathogens (pathogens or bacteria or other germs), then that species or subspecies is called the "reservoir population" of that pathogen. Now, if that "reservoir population" comes in contact with a "novel host population" or an organism of a species or subspecies that was not a carrier of that pathogen at all, that pathogen enters their body and thus from one species or subspecies to another. The mechanism of transmission of the pathogen is called "spillover infection". After entering the "Novel Host Population", the pathogen may or may not spread too much into the "Novel Host Population".
The "reservoir population" of the virus is not yet known, but it is suspected that the animals somehow became the "novel host" of the virus through "spillover infection" and then entered the human body from the animal's body.

Infection in humans

When an infected person sneezes or coughs at a distance of six feet or less, drops of fluid secreted from his nose or mouth that carry this virion; Healthy people are more likely to get it in the nose, mouth, or eyes. As a result, human-to-human transmission spreads.

SARS-COV-2 virions are transmissions from massive objects or surfaces

Various features of the surrounding environment such as - Ph.D. (Unit of measurement of how acidic or alkaline an aqueous solution is) Value, voltage, in chromophores Or an atom or radical of a charged element (called an "ion") density, Phosphorylation (the chemical reaction of a phosphorylated molecule to a molecule of a substance), the addition of a ligand to an organic molecule by a biochemical reaction to form more molecular weight molecules or complexes, etc. As a result, the molecule may lose its normal activity.

As I said before, the envelope of this variant; "Spike protein", "envelope protein", "membrane protein" - these three types of proteins are made up of molecules. The proteins in the envelope of the SARS-CV-2 virion may become inactive due to environmental influences during a long time outside the carrier body, resulting in the virion losing the ability to enter the carrier cell. 

Experimental observations show that these virions are active for eighteen hours on copper, fifty-five hours on cardboard, ninety hours on stainless steel, and more than a hundred hours on plastic. The SARS-COV-2 virion is active in aerosols for three hours. The virus has also been found to be active in human and animal feces.

When the envelope of SARS-CV-2 virions on an object or surface is active, a person can become infected if they touch the nose, mouth, or eyes after touching that object or surface.

Covid-19 possible ways to cure the disease:

We've already got a lot of tips on how to avoid the SARS-Cav-2 variant. But after entering this virion body, we will now discuss how to get rid of its ill effects, i.e. a possible way to cure Kovid-19 disease. We know that the SARS-CV-2 virus belongs to the "Severe Acute Respiratory Syndrome Related Coronavirus" species. 

I am proposing a possible way to prevent the reproduction of all viruses of the "severe acute respiratory syndrome-related coronavirus" species, not just the SARS-CV-2 virus, but needless to say. It will also be possible to cure the disease. Let us first understand how all the viruses of the "Severe Acute Respiratory Syndrome Related Coronavirus" species reproduce in human cells-

The reproductive system of "Severe Acute Respiratory Syndrome Related Coronavirus"

After the virion particles enter the human cell, the nucleocapsids of the virus enter the cytoplasm of the human cell and there the "RNA" of the virus Is free from nucleocapsids. The virus inactivates the human cell's own "messenger RNA". The "ribosome" of the human cell then receives only the "RNA" of the virus in the human cell as active, following the nucleotide sequence in two-thirds of the total length of the "RNA". Types of polyprotein molecules (polyprotein molecules are many relatively small protein molecules that form a long chain-like molecule joined together by covalent bonds) - "PP1A" and "PP1AB". Each polyprotein molecule or chain contains three different enzyme or enzyme molecules - "protease", "paper." Or “papain-like proteins” and “3clpro” that help break down polyprotein molecules. Sixteen types of "non-structural proteins" are formed by breaking down the "PP1AB" polyprotein - "NSP1", "NSP2", 6, "NSP17". Some of these "nonstructural proteins" are called "nonstructural replication proteins" because they act as "replication proteins". Again, some of the "nonstructural replication proteins" combine with each other to form a "replication-transcriptase complex" consisting of many protein molecules. The main "replication-transcriptase" protein present in this complex is "RNA. Dependent R.N.A. Polymerase "or" NSP12 "which plays a major role in the" transcription "and" replication "of viruses. 

However, the rest of the "nonstructural proteins" present in the complex also help in the process of "transcription" and "replication". This "transcription" and "replication" process replicates the "RNA" of the virus, creating a new "RNA" for the next generation of viruses. Is created. In this context, let us say that the enzyme “NSP1” protein and “papain-like proteinase” play an important role in weakening the immunity of the human body. Also, the NSP1 protein is one of the key factors in the destruction of the human cell's own "messenger RNA" and inhibits the normal "translation" process of the human cell.

Prevention of "papain-like proteinase" enzyme produced in human cells infected with "Severe Acute Respiratory Syndrome Related Coronavirus"

The enzyme "papain" is found mainly in raw papaya. It is used in various food and pharmaceutical industries, such as for cleaning blurred lenses, for softening meat, for the lysis process of underarms, for the treatment of Hymenoptera and jellyfish bites. The papain enzyme is also used as an additive in laxatives, tooth powder, digestive pills, and skin lotions. Many people who make a living as workers in these industries are exposed to the "papain" enzyme and many suffer from physical ailments such as shortness of breath, chest pain, cough, etc., which are among the symptoms and symptoms of "Covid-19" disease. Therefore, shortness of breath, chest pain, and cough are seen in patients with "Covid-19"; This may be due to the presence of "papain-like proteinase" enzymes produced by the virus in their infected cells. If we apply anti-enzyme (papain-like proteinase) enzyme (anti-enzyme is a substance, especially an antibody or an enzyme that inhibits the action of another enzyme) in the body of "COVID-19" patients to prevent papain-like proteinase enzyme- However, the "PP1AB" polyprotein molecule cannot be broken down to form "nonstructural proteins" and the virus may stop reproducing.

The "papain" enzyme-dependent industries that we have already mentioned may have some of these long-acting people producing such anti-enzymes, but it is a matter of experimentation.